Direct (nonstop) flights from Panama City to Santa Cruz
2 airlines fly nonstop from Tocumen International (PTY) to Santa Cruz (VVI). It's 2,145 miles (3,452 km), about 5h 1m in the air. Operated by Copa Airlines, Boliviana de Aviación.
Copa Airlines
Boliviana de Aviación
Route data last updated: May 29, 2026
Airlines with non-stop flights
OB
Boliviana de Aviación
Alternative Routes
Other ways to fly from Panama City to Santa Cruz with one stop · direct emits 362 kg CO₂ per passenger
Looking for the return flight?
VVI → PTY: Flights from Santa Cruz to Panama CityOther direct flights from Panama City
Direct flights from Santa Cruz (VVI)
Frequently Asked Questions
How long is the direct flight from Panama City to Santa Cruz?
A nonstop flight from Panama City (PTY) to Santa Cruz (VVI) takes approximately 5 hours and 1 minutes. The distance is 2,145 miles (3,452 km).
Which airlines fly nonstop from Panama City to Santa Cruz?
2 airlines: Copa Airlines, Boliviana de Aviación.
Is there a nonstop flight from Panama City to Santa Cruz?
Yes. 2 airlines: Copa Airlines, Boliviana de Aviación.
How far is Panama City from Santa Cruz?
The flight distance from Panama City to Santa Cruz is 2,145 miles (3,452 km), measured as the great-circle (shortest air) distance. That's roughly the same distance as New York to Los Angeles.
What is the time difference between Panama City and Santa Cruz?
Santa Cruz is 1 hour ahead of Panama City. (America/Panama vs America/La_Paz.)
What type of aircraft flies from Panama City to Santa Cruz?
At 5h 1m, this route typically uses narrow-body or mid-range jets — Boeing 737 MAX or Airbus A320neo. Varies by airline.
Do I need a visa to travel from Panama to Bolivia?
Depends on your passport. Check with the Bolivia embassy or an official visa portal before booking — requirements change.
What is the carbon footprint of a flight from Panama City to Santa Cruz?
Roughly 362 kg CO2 per passenger one-way. That's about the same as driving 1,810 km.
Is the return flight from Santa Cruz to Panama City also nonstop?
Yes — nonstop flights run both ways. Flight time may differ slightly due to wind patterns.
When is the cheapest time to fly from Panama City to Santa Cruz?
Midweek flights (Tue/Wed) outside holiday peaks are usually cheapest. For long-haul, booking 2-3 months out tends to help. Use "Check Prices" above to compare.
How early should I arrive at Tocumen International for this flight?
3 hours before departure for international flights. You need time for check-in, security, and immigration.